Stereocontrol in Solid-Phase Radical Reactions: Radical Addition to Oxime Ether Anchored to Polymer Support

摘要

A high degree of stereocontrol in solid-phase radical reactions was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature. Alkyl radical addition to Oppolzer's camphorsultam derivatives of oxime ether anchored to polymer support proceeded smoothly to give the α-amino acid derivatives with excellent diastereoselectivities.