Ligand Substituent Effects on Asymmetric Induction. Effect of Structural Variations of the DIOP Ligand on the Rh-Catalyzed Asymmetric Hydrogenation of Enamides

摘要

Substituent changes in the ligand (L~*) backbone and the chelating phosphorus atoms of the classical DIOP ligand result in dramatic changes in the enantioselectivity of Rh~+L~*-catalyzed enamide hydrogenations.