Synthesis of Fused Polycycles from Propargylic Compounds with Terminal Alkynes via a Palladium-Catalyzed Tandem C-H Activation/Biscyclization Process

摘要

Various benzo[b]fluorene and fluorene derivatives have been prepared from propargylic compounds with terminal alkynes through a novel palladium-catalyzed tandem biscyclization reaction. This reaction involved a sequence of carboannulation, coupling, C-H activation and C-C bond formation process. A plausible mechanism has been proposed that was consistent with the deuterium-labeling experiment.