Electrophilic Cyclization of 2-(1-Alkynyl)-2-alken-1-ones Using the I_2/K_3PO_4 System:An Efficient Synthesis of Highly Substituted lodofurans

摘要

The electrophilic cyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of various alcohols or carbon-based nucleophiles offers an efficient and straightforward route to highly substituted iodofurans under extremely mild reaction conditions.The iodo derivatives are potential synthetic intermediates for amplification of molecular complexity.