Effects of different reaction conditions on the synthesis of 2-hydroxy-4-n-octaoxybenzophenones (UV-531)

摘要

2,4-dihydroxybenzophenone (UV-214) reacted with 1-bromododecane in KOH solution to produce 2-hydroxy-4-n-octaoxybenzophenones (UV-531). Effects of different reaction conditions such as the amount of catalyst, the amount of water and the reaction time on the synthesis of 2-hydroxy-4-n-octaoxybenzophenones have been discussed. The optimum molar ratio of 2,4-dihydroxybenzophenone to KOH to 1-bromododecane to dimethyl cetyl ammonium chloride to water and the reaction time were 0.06:0.07:0.06:0.002:0.25 and 6 hours, respectively. The experimental results showed that the yield of 2-hydroxy-4-n-octaoxybenzophenones by adding dimethyl cetyl ammonium chloride into the reaction mixture reached 93.2 %. It was found that dimethyl cetyl ammonium chloride was an ideal phase transfer agent.