Soft tissue optical property extraction for carcinoma cell detection in diffuse optical tomography system under boundary element condition

摘要

Near infrared (NIR) light propagation through soft brain tissue extracts the optical properties of tissue. NIR light is a non-invasive technique which exhibits a high penetration depth to depict the morphological tissue characteristics. Laser sources of NIR wavelength 780 nm and 850 nm incident on the surface of the tissue enhances photon propagation through their profile layers. The avalanche photodiode voltage extracts the optical properties as absorption and scattering coefficients. These parameters were obtained at different depths with different tissue diameters, analyzed by simulation results. Diffuse reflectance and fluence rate measurements under time domain were carried out are provided with analytical solutions. The analytical solution for tissue structure configuration was performed at different boundary conditions as spherical or cylindrical or slab structures with photon propagation through an infinite medium. Simulation results of absorption coefficient (mu a < 1 cm(-1) for normal), scattering coefficient (psi < 50 cm-1 for normal) and diffuse reflectance (Rd occurrence of reflections >4 ns time for normal) differentiates the normal cells from carcinoma cells. Error percentage calculated for our system at 780 nm and 850 nm wavelength were minimum, as pa (780 nm)= 0.58%, mu s' (780 nm) = 0.1%, mu a (850 nm) = 0.2%, mu' (850 nm) = 0.2% when compared with existing system. Crown Copyright (C) 2015 Published by Elsevier GmbH. All rights reserved.