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Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Pancreatic Islets from Zucker Diabetic Fatty Rats

机译:Roux-en-Y胃旁路对祖克糖尿病大鼠胰腺胰岛NLRP3炎性体的影响

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Purpose Diabetes and obesity are associated with inflammasome-mediated low-grade, chronic inflammation that may induce pancreatic beta-cell dysfunction and apoptosis. We examined the effects of Roux-en-Y gastric bypass (RYGB) surgery on NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome-related genes from pancreatic islets of Zucker diabetic fatty rats.
机译:目的糖尿病和肥胖与炎症小体介导的低度慢性炎症相关,可能诱发胰腺β细胞功能障碍和细胞凋亡。我们检查了Roux-en-Y胃旁路手术(RYGB)对NOD样受体家族,来自Zucker糖尿病性脂肪大鼠胰腺胰岛的含有3(NLRP3)炎症小体相关基因的吡啶结构域的影响。

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