Functional proteomics to exploit genome sequences.

摘要

The sequencing of various genomes has inaugurated a new stage in the understanding of normal and pathological cell function through the analysis of the role of proteins. Proteins, after all, that intervene in the different molecular mechanisms of life, during growth, reproduction, and in the interaction between cells, thus making it possible to describe the biology of integrated systems. In this article, we briefly describe the various stages in the progression of our knowledge, from the genome to the "functional" proteome. Emphasis is placed on a global approach to the protein-protein interactions used to describe the cellular "interactome".