Resemblance for body mass index in families of obese African American and European American women.

摘要

OBJECTIVE: We determined the levels of resemblance in body mass index (BMI) in large samples of families selected through obese African American and European American women. RESEARCH METHODS AND PROCEDURES: We examined correlations among relatives in 1,185 European American and African American families ascertained through age-matched obese women (BMI > or = 30 kg/m2). A subset of 801 families were ascertained through extremely obese women (BMI > or = 40 kg/m2). RESULTS: Parent-offspring and sibling correlations ranged from 0.19 to 0.15, suggesting a moderate level of heritability in both groups. Mean BMI values for female relatives were lower for European Americans than for African Americans even though probands were matched, perhaps because the European American relatives regress to a lower population mean. We found significantly higher family correlations for height in European Americans, suggesting greater environmental variability among African Americans for factors affecting growth and physical development. DISCUSSION: Our results suggest a similar level of heritability of BMI in families of obese African American and European American women. Other genetic studies will be needed to determine the extent to which the same or different genes and environmental conditions contribute to an overall similar heritability in the two racial groups.