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首页> 外文期刊>Oncology letters >Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report
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Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report

机译:表现为双侧锁骨上淋巴结转移的隐匿性卵巢癌患者的循环肿瘤细胞液体活检:一例报告

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摘要

Metastases to the supraclavicular region usually originate from the head and neck or from infraclavicular tumors. Ovarian primaries of supraclavicular metastases are extremely rare. The present study reports the case of a 60-year-old patient with a bilateral supraclavicular mass that was diagnosed as a poorly-differentiated squamous cell carcinoma of unknown primary, following a fine-needle aspiration biopsy (FNAB) and comprehensive clinical investigation. The analysis of a peripheral blood sample using the CellSearch system revealed the presence of circulating tumor cells (CTCs) that were positive for epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK) expression. Since EpCAM is usually expressed in adenocarcinoma, an excisional biopsy of the right supraclavicular lymph node was performed. The patient was diagnosed with occult ovarian low-grade serous carcinoma by immunohistochemistry. To the best of our knowledge, this is the first report to demonstrate that CTCs may be detected in the peripheral blood of a patient with cancer of unknown primary (CUP) by using the CellSearch system. A literature review was performed to analyze the diagnostic procedures of CUP metastatic to the cervical lymph nodes and the clinical features of CTCs.
机译:锁骨上区域的转移通常起源于头颈部或锁骨下肿瘤。锁骨上转移的卵巢原发非常罕见。本研究报告了一例60岁的双侧锁骨上包块患者,经细针穿刺活检(FNAB)和全面的临床研究后,被诊断为原发性不明的低分化鳞状细胞癌。使用CellSearch系统对外周血样品进行的分析显示,存在循环肿瘤细胞(CTC),这些细胞对上皮细胞粘附分子(EpCAM)和细胞角蛋白(CK)表达呈阳性。由于EpCAM通常在腺癌中表达,因此对右锁骨上淋巴结进行切除活检。通过免疫组织化学诊断为隐匿性卵巢低度浆液性癌。据我们所知,这是第一份证明使用CellSearch系统可以在患有未知原发性癌症(CUP)的患者的外周血中检测到CTC的报告。进行了文献综述,以分析转移至宫颈淋巴结的银联的诊断程序和四氯化碳的临床特征。

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