Reducing cell number improves the homing of dendritic cells to lymph nodes uponintradermal vaccination.

摘要

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes(LNs). Unfortunately, however, DC migration rates are typically very poor. Weinvestigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injectionsite, improved LN targeting.