Synchronous apoptosis in established tumors leads to the induction of adaptiveimmunity.

摘要

Understanding the immune response to the death of malignant cells is critical forthe development of therapeutic strategies designed to stimulate the immune systemagainst cancer. We have developed an inducible caspase-3-mediated death switchmodel to explore the effects of apoptosis on the host immune system,demonstrating that the synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.