Interferon gamma/NADPH oxidase defense system in immunity and cancer

摘要

As a part of cellular pathogen defense, IFN gamma triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFN gamma-mediated anticancer control. IFN gamma is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence.