Intravaginal live attenuated Salmonella increase local antitumor vaccine-specific CD8(+) T cells.

摘要

We have recently reported that the intravaginal instillation of syntheticToll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccinationagainst human papillomavirus E7 highly increases (~5-fold) the number ofvaccine-specific CD8(+) T cells in the genital mucosa of mice, without affecting E7-specific systemic responses. Here, we show that the instillation of liveattenuated Salmonella enterica serovar Typhimurium similarly, though moreefficiently (~15- fold), increases both E7-specific and total CD8(+) T cells inthe genital mucosa. Cancer immunotherapeutic strategies combining vaccinationwith local immunostimulation with live bacteria deserve further investigations.