Giving Alzheimer's the Old One-Two

摘要

A dual goal for treating Alzheimer's disease (AD) is to decrease deposition of neurotoxic amyloid β-peptide in the brain and to boost repair of damaged neurons. Donmez et al. (2010) now show that SIRT1 may mediate both processes by deacetylating the transcription factor retinoic acid receptor β, a potential new therapeutic target for AD.