Reaction of 3-aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones with substituted acetamides of 3,4-dihydroisoquinolines

摘要

3-Aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones react with substituted [3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides and {2,3-dihydrobenzo[f]isoquinolin-4(1H)-ylidene}acetamide to produce substituted 1,5,5',6'-tetrahydro-3'H-spiro(pyrrole-2,2'-pyrrolo[2,1-a]-isoquinoline)-1'-carboxamides and 13-aza-analogs of steroids, substituted 5H-spiro(benzo[f]pyrrolo[2,1-a]isoquinoline-9,2'-pyrrole)-10-carboxamides respectively.