Genome-Wide Association Study of Height-Adjusted BMI in Childhood Identifies Functional Variant in ADCY3

摘要

ObjectiveGenome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that kg/m(2) is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children.