A roundabout way to the niche.

摘要

A new player in hematopoietic stem cell (HSC)-niche interactions is introduced in this issue of Cell Stem Cell. Smith-Berdan et al. (2010) demonstrate that Robo4 is involved in HSC engraftment and mobilization and does so in cooperation with Cxcr4 to guide stem cells to and secure them in the niche.