Metastases from a gingival Squamous Cell Carcinoma (SCC) in a dog.

摘要

This article describes clinical, gross and histological findings and distant metastases from a gingival squamous cell carcinoma (SCC) that mimicked chronic gingivitis and periodontitis in its early presentation in the right maxillary area of a 6-year-old male terrier dog in Turkey [date not given]. At necropsy, no maxillary teeth on all over the maxilla were observed and the right maxillary bone was completely destroyed. Greyish-brown or mostly reddish-brown ulcerated and irregular tumoural masses markedly invaded this area and the left mandible. Metastases to lungs, mediastinal lymph nodes, liver, kidneys and cerebellum were found. Histologically, the metastatic and primary masses consisted of islands and cords with many intercellular bridges and intensely eosinophilic keratinized centres with well squamous differentiation. Strongly cytokeratin positive staining of tumoural cells revealed by immunohistochemistry confirmed the epithelial origin of the primary tumour and of its metastases. This is the first report of a well differentiated squamous cell carcinoma with distant metastases to the cerebellum and liver in a dog.