Cell-free fetal DNA and adverse outcome in low risk pregnancies

摘要

Preeclampsia is a common, serious pregnancy-related disorder of unknown etiology. It might be initiated by placental factors that enter the maternal circulation. Previous reports of increased free fetal DNA in maternal plasma before the clinical onset of preeclampsia have been promising. The aim of this study was to determine whether free fetal DNA in maternal plasma of the second trimester is associated with the development of preeclampsia and whether free fetal DNA could be a potential indicator of an increased risk for preeclampsia or small-for-gestational-age (SGA) infants.