Synthesis, Spectral, Thermal and Biological Studies of Co(III) and Binuclear Ni(II) Complexes with a Novel Amine-Imine-Oxime Ligand

摘要

Two different metal complexes of [Co(HL)(L)(Ac)2],4H2O (I) and [Ni2(L)2(Ac)2].4H2O (II), have been synthesized with newly prepared amine-imine-oxime ligand [HL = 3-(4'-aminobiphenyl-4-ylimino)-butan-2-one oxime, Ac = CH3COO~- ]. This ligand HL was prepared by the condensation of diacetylmonoxime with benzidine. The structure of the ligand and complexes have been proposed by elemental analyses, IR, ~1H, and ~(13)C NMR, electronic spectra, magnetic susceptibility measurements, mass spectra, molar conductivity and thermo gravimetric analysis. The molar conductance measurements of the complexes in DMF solution correspond to non electrolytic nature for the complexes. Octahedral and tetrahedral geometries have been determined to the complexes of Co(III) and binuclear Ni(II) respectively. The ligand and its metal complexes were tested in vitro for their biological effects. Their activities against two gram-positive (Bacillus subtilis and Staphylococcus aureus) and one fungal specie (Candida albicans) were found. They were inactive against tested gram negative bacteria.