A New Route to N-(1-Adamantyl)nicotinamide

摘要

N-(1-Adamantyl)nicotinamide I was prepared previously by the reaction of nicotinoyl chloride with 1-aminoadamantane on heating in anhydrous pyridine [1]or by the Ritter reaction [2]from 1-hydroxyada-mantane and nicotinonitrile in trifluoroacetic acid acting as catalyst and solvent.