NMR Study of 1,7-Diamino-4-oxyheptane-1,1,7,7-tetraphosphonic Acid Interaction with Samarium(III) Cation

摘要

1,7-Diamino-4-oxypentane-1,1,7,7-tetraphosphonic acid has been synthesized while searching for potential components for Sm-153 radiopharmaceuticals. Its interaction with samarium( III) cation has been studied by C-13 and P-31 NMR spectroscopy in comparison with 1,5-diamino-3-oxypentane-N,N'-tetra(methylenephosphonic acid) which is the ligand component of the osteotropic drug Samarium Sm-153 oxabifore. NMR spectroscopy provides a simple, convenient, and informative method for studying interactions between the ligand and prospective radionuclide cation.