Microwave Assisted Reactions of Imidazole Derivatives of Potential Practical Applications

摘要

A fast, general and facile method for preparation of 1,3-diazol salts via N-alkylation reactions under conventional heating and microwave irradiation is presented. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. A comparative study of microwave versus classical heating (liquid solvents) has been done. Sixteen new 1,3-diazol salts of potential practical interest were obtained.