Synthesis of 6(E) - and 6(Z) -(3-ethoxycarbonylpropyl)oximes of 16#alpha#, 17#alpha#-cyclohexanopregn-4-ene-3,6,20-trione and study of their interaction with proteins of the rat uterine cytosol and blodd serum

摘要

6(E)- and 6(Z)-(3-Ethoxycarbonylpropyl)- and -(3-carboxypropyl)oximes of 16#alpha#,17#alpha#-cyclohexanopregan-4-ene-3,6,20-trione were synthesized. The reaction of these ester ligands with pentarane-binding proteins of the uterine cytosol and blood serum were studied; the latter exhibits a higher affinity. The preferred binding of the oxime (E)-isomer relative to the (Z)-isomer was noted.