Chemistry of Natural Compounds, Bioorganic, and Biomolecular Chemistry Fluorescent-labeled derivatives of dolichyl phosphate. Analogs of dolichyl phosphate with the 2-aminopyridine residue at the #omega#-end of the chain

摘要

A simple approach to the synthesis of dolichyl phosphate derivatives with a fluorescent label, 2-aminopyridine residue, at the #omega#-end of the chain was developed. The method includes selective van Tamelen epoxidation of the #omega#-isoprene unit in dolichyl acetates, transformation of the epoxides to #omega#-terminal aldehydes, their reductive amination, and phosphorylation of the resulting amino alcohols.