Synovial fluid and serum levels of IL-17, IL-23, and CCL-20 in rheumatoid arthritis and psoriatic arthritis: A Tunisian cross-sectional study

摘要

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by abnormal synovial hyperplasia associated with local infiltration of various inflammatory cells leading to cartilage and bone destruction. Interleukine-17-producing T helper (Thl7) cells are a recently discovered effectors T-lymphocyte subset that plays a critical role in several chronic inflammatory diseases, like RA and psoriatic arthritis (PsA) [1-4]- The objective of our study was to appreciate the role of inter-leukine (IL)-17, IL-23, the major Thl7 driving cytokine, and CCL-20, a major Thl7-attracting chemokine in the regulation of RA and PsA, by comparing concentrations in sera and in knee synovial fluid (SF) among three groups of patients, one with an active form of RA, one with active peripheral psoriatic arthritis PsA and a control group of osteoarthritis (OA) (Table 1).