Extremity exposure in nuclear medicine therapy with ~(90)Y-labelled substances - Results of the ORAMED project

摘要

~(90)Y-labelled radiopharmaceuticals offer promising prospects for radionuclide therapies of tumours, e.g. radioimmunotherapies (RIT), (EANM, 2007), peptide receptor radiotherapies (PRRT), (Otte et al.; 1998), and selective internal radiotherapies (SIRT), (Salem and Thurston, 2006). ~(90)Y, an almost pure high-energy beta radiation emitter (E _(β,max) = 2.28 MeV), is a favourable radionuclide for therapeutic purposes. However, when preparing and performing these therapies, high activities of ~(90)Y (>1 GBq) are to be manipulated and technicians, physicians and nurses may receive high skin exposures to the hands. If radiation protection standards are low, the exposure of staff can exceed the annual skin dose limit of 500 mSv. Within a particular work package (WP4) of the ORAMED project, comprehensive measurements in nuclear medicine departments of several hospitals in 6 European countries were carried out. The study focussed on ~(90)Y-labelled substances such as Zevalin~? and DOTATOC to achieve a representative database on staff exposure. This paper summarises the most important results and conclusions for individual monitoring of skin exposure of staff.