Insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme gene in steroid-resistant nephrotic syndrome for children: An updated meta-analysis

摘要

Steroid-resistant nephrotic syndrome (SRNS) is a risk disease in children and is prone to develop into end-stage renal disease. Some investigations suggested that the genetic factor might play an important role in the susceptibility of SRNS. We performed a meta-analysis to explore the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and SRNS risk and conducted the search on 1 September 2010.1 We found that D allele and DD genotype were not associated with the risk of SRNS. However, Prasun et al. 2 reported an investigation on the association of ACE I/D gene polymorphism with SRNS risk in 2011, but we did not include this study for our meta-analysis. They reported that the frequency distribution of the DD homozygous was markedly high in the SRNS group compared with that in the control subjects. Read More: http://informahealthcare.com/doi/full/10.3109/0886022X.2011.653751