Ru-106 radiolabelling of the antitumour complex (eta(6)-fluorene)Ru(en)ClPF6

摘要

The organometallic half-sandwich Ru-II arene anticancer complex ( eta(6)-fluorene) Ru( en) Cl PF6 ( 1) has been synthesized in high yield and purity on a micromole scale with incorporation of the beta-emitting radioisotope Ru-106 ( half-life = 1.01 y) using a refined procedure involving conversion of RuCl3 into ( eta(6)-fluorene)RuCl2(2), and then (eta(6)-fluorene)Ru(CH3CN)(2)ClPF6 as intermediates. Distribution studies 0.25 h post i.v. injection of Ru-106-1 at a dose of 25 mg 1 kg(-1) show that Ru-106 is well distributed throughout the tissues of a rat. This appears to be the first report of the radiolabelling of a potential ruthenium antitumour agent for distribution/biological studies.