Disturbance of sensorimotor filtering in the 6-OHDA rodent model of Parkinson's disease

摘要

Aims: Parkinson's disease (PD) is a movement disorder that involves non-motor symptoms including cognitive dysfunction. L-DOPA (L-3,4-dihydroxyphenylalanine), the most effective treatment for PD, might cause the development of abnormal involuntary movements and psychotic symptoms. It has been argued that a complex interaction between drug- and intrinsic disease-related components is enrolled in PD psychotic symptoms. Prepulse inhibition (PPI) is a cross-species measure of sensorimotor gating often disrupted in disorders either with basal ganglia dysfunction or with psychotomimetic drugs. There are controversial results concerning PPI in PD patients. Nevertheless, clinical studies are difficult to interpret because of differences in disease severity, concomitant medications, and comorbidities. Our aim was to investigate the functioning of sensorimotor gating in the 6-OHDA-inducing partial or complete dopaminergic degeneration of the nigrostriatal pathway.