Method of the month - prediction of protein secretion systems in bacterial genomes

摘要

For most bacteria it is essential to secrete particular proteins,and there are several methods available for predicting which proteins will be secreted and how.This genome update deals with characterization of secretion systems in bacterial genomes.Next month,the prediction of secreted proteins will be described,and the following month we will look at prediction of membrane proteins and combining all this to characterize where all the proteins in a given bacterial proteome are likely to be localized - for Gram-negative bacteria,there are five possibilities:the cytosol ('inside'),embedded in the inner membrane,periplasm,outer membrane or secreted ('outside').