Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C-C Bond Forming Reactions

摘要

A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-cata-lyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 °C could be obtained.