CD44, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1: Biomarkers in search of validation in lymphomas

摘要

In this issue of Leukemia and Lymphoma, Shah and colleagues report on the ability of three exploratory biomarkers to predict the outcomes of patients with indolent lymphoma [1]. The investigators found that three proteins that mediate the interaction between lymphoma cells and the microenvironment (CD44, intercellular adhesion molecule-1 [ICAM-1] and vascular cell adhesion molecule-1 [VCAM-1]) were associated with progression-free survival and overall survival (although only ICAM-1 maintained its predictive value in a multivariate analysis).