Hodgkin lymphoma and interleukin-10: shall we go down from the tip of the iceberg?

摘要

Hodgkin lymphoma (HL) is a malignant lympho-proliferation most commonly affecting young adults. Although the disease was first described more than 150 years ago, unraveling the pathogenesis and cellular nature of HL has been painstakingly slow . Two findings, in particular, make HL a unique malignant hematopoietic disease: first, the malignant mononucleated Hodgkin- and the multinucleated Reed-Sternberg (HRS) cells represent only a small fraction of cells in the affected lymph nodes and are embedded in an infiltrate of reactive hematopoietic cells .