Synthesis of oxepin-annulated quinolone heterocycles by ruthenium catalyzed enyne bond reorganization/Diels-Alder reaction

摘要

Synthesis of oxepin-annulated quinolone heterocycles by the combination of Claisen rearrangement, the ring-closing metathesis and Diels-Alder reaction is described. The RCM or RCEM proceeded smoothly in the presence of Grubbs' first generation catalyst at room temperature under nitrogen atmosphere.