Green Synthesis of Novel Phthalimide Derivatives of Aspirin and P-amino-salicylic Acid as Potential Analgesic- antipyretic and Anti-tuberculosis Agents

摘要

Green synthesis of novel compounds 4-(2-carboxybenzamido)-2-hydroxybenzoic acids 3a-3e, 4-(1, 3-dioxoisoindolin-2-yl)-2-hydroxybenzoic acids 4a-4e, 2-acetoxy-4-(2-carboxybenzoylamino)benzoic acids 6a-6e and 2-acetoxy-4-(1, 3-dioxo-l, 3-dihydroisoindol-2-yl)-benzoic acids 8a-8e has been developed which were analogs of aspirin (used as analgesic, anti-pyretic and cardiovascular drug) and para-aminosalicylic acid (used as anti-tuberculosis agent).