The use of enantiomerically pure alpha,beta-unsaturated N-acyloxazolidin-2-one in diastereoselective Baylis-Hillman type reaction mediated by SMI2

摘要

(R)-3-(2-Bromo-3-phenyl-acryloyl)-5,5-dimethyl-4-phenyl-oxazolidin-2-one 3 which is readily available from (R)-phenylglycine, was shown to be an effective chiral auxiliary for stereoselective Baylis-Hillman type reaction with aldehydes in the presence of Sml(2).