Solid Phase Synthesis of 7-Hydroxy-3,10-dihydro-1H-1,4diazepino5,6-bindol-2-ones

摘要

Indoles probably represent the most important of all structural classes in drug discovery.The indole nucleus is a fundamental constituent of a number of natural and synthetic products with biological activity.Actually there are so many compounds containing this ring that it is nearly impossible to catalog their complete range of biological activity.This basic skeleton for example presents itself in the neurotransmitter Serotonin 1,5-hydroxytryptamine,(5-HT),which plays an important role in a variety of processes through the activation of 5-HT receptors.