Investigation of the Aggregation and Disaggregation Properties of Erythrocytes by Light Scattering Measurements

摘要

Different analytical methods are used for blood diagnostics on clinical conditions. The aggregation and disaggregation behavior of erythrocytes reflects pathological states of the human body. In the present paper the aggregation and disaggregation process of human blood samples is investigated by remission measurements. The whole blood samples were analyzed using a rotating coaxial cylinder system in combination with a special method for data processing. The erythrocyte aggregates were destroyed completely without injuring the cell membranes by shear forces arising during the cylinder rotation. The time behavior of the remission signal during the aggregation process was investigated. The disaggregation process was characterized by the dependence of the remission signal intensity on different applied shear rates. A correlation of the aggregation and disaggregation behavior to different diseases was found. In the present paper the analytical method was used to diagnose the diabetes diseases.