Nitrite to nitrate molar ratio is inversely proportional to oxidative cell damages and granulocytic apoptosis at the wound site following cutaneous injury in rats

摘要

Wound healing represents an organized effort to reestablish tis-sue integrity following an injury, involving both inflammation and the resolution of the inflammatory response including apoptosis of inflammatory cells infiltrating the injured region [1,2]. The partic-ipation of nitric oxide (NO) both in apoptosis of the various cells [3-5] and in wound healing [2,6] has already been documented, but its role(s) in these processes have not been completely defined, yet. Despite the establishment of the important role of NO in apop-tosis, a molecular-level understanding of the origin of its dichoto-mous pro- and antiapoptotic effects seems elusive, while computations point to the importance of precise timing of NO pro-duction [7]. Moreover, the question when this Janus-faced mole-cule is good, and what makes it bad, still needs to be resolved [8-10].Although some injuries increase [11-13], while the others de-crease [14] NO production, increased NO formation at a wound site seems to be undoubtedly documented fact [15-17]. In response to