RAMAN SPECTROSCOPY: Spatial offset broadens applications for Raman spectroscopy

摘要

While Raman spectroscopy in the backscattering collection mode is limited to probing shallow, semitransparent media, a new offset method improves penetration depth. In many analytical applications it is necessary to ascertain the chemical composition of deep layers in diffusely scattering (turbid) samples. Examples include the noninvasive probing of living tissue in disease diagnosis or the noninvasive probing of pharmaceutical tablets and capsules in quality control. Raman spectroscopy holds particular promise in this area because of its high chemical specificity, compatibility with water-containing samples, and ease and speed of implementation.