Grafting of oxidized carboxymethyl cellulose with hydrogen peroxide in presence of Cu(II) to chitosan and biological elucidation

摘要

The chemical interaction of chitosan (CS) is performed in the presence of sodium carboxymethyl cellulose (CMC) and/or oxidized CMC. The latter is obtained by the action of H2O2/CuSO4 to generate carbonyl and carboxyl groups which were increased with CuSO4 concentration. The characterization of these new materials is made by FTIR, TGA, XRD and SEM. Examination of the hemolytic potential showed that the hydrogels were non hemolytic in nature. The hydrogels were non-toxic and blood-compatible. The antibacterial and antioxidant activities of samples were investigated. (C) 2017 Published by Elsevier B.V. on behalf of Nalecz Institute of Biocybemetics and Biomedical Engineering of the Polish Academy of Sciences.