Rapid UHPLC Determination of Common Preservatives in Cosmetic Products

摘要

P-hydroxybenzoic acid esters, also called parabens, are widely used as antimicrobial preservatives in cosmetic products. Parabens have a potential of endocrine effect — as a result, their use is limited in EU countries to a maximum concentration of 0.4% when used individually and 0.8% as a mixture. In the US, is against the law to market products with ingredients that may eause injuries under label conditions, thus parabens are typically used. at levels between 0.01 to 0.3%. This application note will resent a fast, sensitive, and reliable UHPLC determination of six common parabens.This application will discuss throughput improvements and uctions in solvent consumption compared to a conventional HPLC analysis of parabens. In addition, method conditions and performance data will be presented.