Improved Clean Up and Recovery of Pharmaceutical Compounds from Plasma using Strata~(TM)-X Solid Phase Extraction (SPE) vs. Traditional Liquid-Liquid Extraction

摘要

Diclofenac is a slightly acidic (pK_a = 4.0) non-steroidal anti-in- flammatory drug (NSAID) that has been used as a post op-erative pain reliever in adult and pediatric patients. The subsequent quantization of diclofenac from the small volumes of biological ma-trices, such as plasma, has been of significant concern. Therefore, this article explores two popular extraction methods, solid phase extrac-tion (SPE) and liquid-liquid extraction (LLE), for the isolation of diclofenac from plasma, using a water matrix as the control.