Helsinn Advanced Synthesis SA Manufacturing Chemist Article: New Cytotoxic Plant - Facility Lay Out, Equipment and Safety Features involved as well as Energy Saving and Environmental Technologies Used

摘要

Helsinn Advanced Synthesis SA, the Chemical Manufacturing business unit of the Helsinn Group, located in Biasca, Switzerland, is expanding into the Cytotoxic Market with construction of a new dedicated Cytotoxic facility. In 1983, the first Chemical Operations of Helsinn opened their doors for classical small molecule Active Pharmaceutical Ingredients (APIs) and Advanced Intermediate manufacturing, for third parties. In 1999, the business grew with the construction of a new building for expansion into manufacturing of Highly Potent Active Pharmaceutical Ingredients (HPAPIs). When this new building was designed, the engineers had containment in mind. Therefore, all of the maintenance was put behind the walls so the only entity in the actual production bay was the reactor and product isolator i.e. pressure filter dryer. This greatly reduces any chance of cross contamination. Additionally, space was left in this building for future expansion which is now being utilized for the dedicated Cytotoxic Plant. The permitting phase began in August 2010 and was granted permission to begin construction in January 2011. Since the groundwork for this plant was laid in 2000, when the new facility was built, the foundation cut off six months of the construction timeline and reduced the cost of investment. Overall this will be an 18 Million CHF investment. With Helsinn's expertise in Highly Potent compounds, we are confident making the transition into the Cytotoxic market.