ENANTIOSELECTIVE EXTRACTION OF KETOPROFEN ENANTIOMERS USING ESTER ALCOHOL R,R-DI-TARTARATES OR S,S-DI-TARTARATES AS CHIRAL SELECTOR

摘要

Distribution behavior of ketoprofen enantiomers was examined in a two-phase system containing R,R-di-tartarates or S,S-di-tartarates.The influences of different alkyl chain of R,R-di-tartarates or S,S-di-tartarates,concentrations of R,R-di-tartarate,organic solvent and content of methanol on partition coefficient and separation factor were investigated,respectively.The experimental results show that R,R-di-tartarates studied all form more stable diastereomeric complexes with ketoprofen S-enantiomer than with R-enantiomer.The partition coefficients and enantioselectivity generally increase with the addition of length of alkyl chain of alcohol.The concentration of chiral selector and methanol also have bigger influences on enantioselectivity.