ENANTIOSELECTIVE TRANSPORT OF L-PROPRANOLOL THROUGH A BULK LIQUID MEMBRANE CONTAINING COMPLEX OF (S,S)-di-n-DODECYLTARTRATE AND BORIC ACID

摘要

A method of bulk liquid membrane using complex of (S, S)-di-n-dodecyltartrate and boric acid was developed for the enantioselective transport of racemic propranolol It was shown that l - propranolol can be effectively transported. The enantioseleetivity of the complex for a specific propranolol enantiomer in BLM systems is mainly based on kinetics and is not thermodynamically driven. The effects of the concentration ratio of propranolol to chiral carrier and the buffer pH were studied, respectively. An appropriate choice for such concentration ratio and the pH in the aqueous solution result to be 1 : 20 and 5, respectively. The developed method is helpful for optimizing the transport of bulk liquid membrane systems and realizing the large-scale production of pure enantiomer.