Inorganic-organic hybrid silica based tin(II) catalyst: Synthesis, characterization and application in one-pot three-component Mannich reaction

摘要

Inorganic-organic hybrid material catalyzed one-pot three-component Mannich reaction of ketones with aromatic aldehydes and different amines at ambient temperatures afforded (Vamino carbonyl compounds in excellent yields. This method provides a novel and improved modification of three-component Mannich reaction in terms of mild reaction conditions and clean reaction profiles, using small amount of catalyst, simple workup procedure and ease of recovery and reusability of catalyst.