Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats.

摘要

72 LEW rats were assigned at random to 2 groups: 1 group was inoculated with Mycoplasma pulmonis, and the other served as an uninoculated control group. On postinoculation day 31, all rats received a single dose of tilmicosin (20 mg/kg of body weight, s.c.). Concentrations of tilmicosin in the lungs of both groups of rats were significantly higher than serum tilmicosin concentrations at all times. Infected rats had significantly higher lung tilmicosin concentrations than non-infected rats. No correlation was found between pH of the lungs and tilmicosin concentration in the lungs in either treatment group; treatment did not have any effect on pH of the muscle. It is concluded that tilmicosin accumulates in the lungs, and infection and inflammationfurther improves its tissue penetration.